Rheumatoid Arthritis: Causes, Symptoms, and Treatment Options
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Rheumatoid Arthritis: Causes, Symptoms, and Treatment Options

Introduction

Are you experiencing pain, swelling, stiffness, and tenderness in more than one joint, or pain and stiffness in the same joints on both sides of your body?

Or does every morning come with body stiffness?

If yes, then this might indicate rheumatoid arthritis (RA), a chronic (ongoing) autoimmune disease. The exact cause of RA is unknown; however, experts like Dr. Ishwar Bohra, with over 23 years of experience, say it can happen due to a combination of genetics, hormones, and environmental factors.

RA affects every person differently; for example, in some people, symptoms develop over several years, and in others, symptoms progress rapidly. Many individuals have periods with symptoms (flares) and then times with no symptoms (remission).

What is Rheumatoid Arthritis (RA)?

RA is a chronic autoimmune disease that contributes to pain, swelling, and stiffness in the lining of your joints (synovium).

It is a type of arthritis where your immune system (which is a complex network of cells, tissues, and organs that protect you from foreign invasion or infection) attacks the tissue lining the joints on both sides of your body.

You can think of this condition like your immune system getting confused and attacking your own joints, as if they don’t belong to your body.

This leads to uncontrolled inflammation that damages cartilage (known to act as a “shock absorber” in your joints). In time, this can deform your joints, and finally, your bone itself erodes, leading to the fusion of your joint(s).

In addition to affecting your joints, RA sometimes affects other parts of your body, such as:

  • Skin
  • Eyes
  • Mouth
  • Lungs
  • Heart

What Is the Main Cause of Rheumatoid Arthritis? Etiology of RA

Due to unknown factors, your immune system mistakenly attacks the synovium (lining of the joints). 

This leads to inflammation and bone erosion.

It can result from the combination of the following factors:

  • Genetics (inherited genes, particularly HLA-DRB1)
  • Environmental factors (e.g., smoking)
  • Hormonal changes
  • Obesity
  • Certain infections

These factors may trigger the immune system to produce antibodies (such as Rheumatoid Factor and Anti-CCP) that target joints.

Women are three times more likely to develop rheumatoid arthritis than men.

What Are the 4 Stages of Rheumatoid Arthritis?

The stages are based on:

  • How much inflammation has happened?
  • How has structural damage occurred in the joints?
Stage Name How This Stage May Look Like
1 Early (early synovitis) The joint lining is inflamed, with pain, stiffness, swelling, and fatigue; there is no obvious deformity.
2 Moderate (cartilage damage) Constant inflammation; reduced joint space; early deformity or misalignment; limited range of motion.
3 Severe (bone erosions and deformity) Cartilage and bone eroded, visible joint deformities (e.g., bent fingers), significant pain, stiffness, and functional loss.
4 End‑stage (joint destruction/fusion) Joint severely damaged or destroyed; may fuse (ankylosis); long-term pain, marked disability; may need joint replacement.

Blood Test for Rheumatoid Arthritis

To make a rheumatoid arthritis diagnosis, your doctor may refer you to a rheumatologist (a doctor who specializes in arthritis).

The experts will do a physical exam and ask you about your medical history and symptoms. 

The rheumatologist will also order the following blood tests and imaging tests for detailed analysis: 

  • The blood tests look for Erythrocyte sedimentation rate (ESR or “sed rate”), C-reactive protein (CRP), Rheumatoid factor (RF) antibodies, and cyclic citrullinated peptide (CCP) antibodies. Their presence is the sign of RA.
  • Imaging tests include X-rays, ultrasounds, and magnetic resonance imaging (MRI) scans. This helps look for signs that your joints are wearing away.

Main Symptoms of RA

The symptoms and their frequency may vary in every individual.

Here are some of the common symptoms:

  • Pain, swelling, stiffness, and tenderness in more than one joint
  • Stiffness, particularly in the morning or after sitting for long periods
  • Pain and stiffness in the same joints on both sides of the body
  • Extreme fatigue, weakness, and fever

Remember, the early signs are vital because the sooner you’re diagnosed with RA, the sooner your treatment can start. Treatment at the right time lowers the risk of developing permanent, painful joint damage.

Rheumatoid Arthritis ICD 10

ICD‑10 is the international coding system for diseases and conditions. 

ICD‑10 diagnosis codes are implemented to classify rheumatoid arthritis in the medical records and billing.

These codes tell hospitals, insurers, and databases what diagnosis the patient  has for documentation and reimbursement.

‑10 code What the Codes Tell You, Hospitals & the Insurers
M05.9 RA with rheumatoid factor, unspecified site
M06.9 RA, unspecified (serostatus/site not specified)
M05.0 Felty’s syndrome (RA with spleen/near‑zero neutrophils)
M05.1 RA with rheumatoid lung disease
M05.2 RA with rheumatoid vasculitis
M06.00 RA without rheumatoid factor, unspecified site
M06.849 RA affecting unspecified hand
M06.839 RA affecting unspecified wrist
M06.859 RA affecting unspecified hip
M06.879 RA affecting unspecified ankle/foot

Is Rheumatoid Arthritis Reversible

Many people ask “how to cure rheumatoid arthritis permanently." RA cannot be fully reversed or cured. Thankfully, it can be controlled and slow the progression with early, aggressive treatment.

The Treatment

It focuses on:

  • Reducing joint inflammation
  • Relieving pain
  • Slowing disease progression

Through a combination of:

  • Medications, DMARDs (disease‑modifying antirheumatic drugs)
  • Biologic DMARDs and JAK inhibitors
  • Supportive drugs
  • Lifestyle adjustments such as healthy weight management, eating joint-friendly food, physiotherapy, joint‑protection techniques, etc.
  • Joint replacement (hips, knees) surgery or synovectomy in severe cases

When is Joint Replacement Surgery or Synovectomy Recommended for RA?

In the following scenarios:

  • Persistent joint pain that makes it difficult to perform daily simple tasks.
  • Major cartilage loss ("bone-on-bone").
  • Severe dysfunction persists.
  • When non-surgical options fail.
  • When an X‑ray or MRI shows severe joint destruction, deformity, or loss of joint space.
  • When the individual is medically fit for surgery.

Synovectomy (removal of inflamed synovium) is recommended when:

  • A single joint (often knee or elbow) has severe synovitis and pain; however, limited bone or cartilage damage.
  • Symptoms do not improve after certain time periods from non-surgical options.

Difference Between Osteoarthritis and Rheumatoid Arthritis

Do not confuse these two; they may look and feel the same. However, here is the simple difference:

Characteristic Osteoarthritis (OA) Rheumatoid Arthritis (RA)
Nature of the Disease Degenerative “wear‑and‑tear” arthritis. Autoimmune inflammatory arthritis
How it Happens Gradual breakdown of joint cartilage due to age, overuse, or injury. The own immune system attacks the synovial lining of joints

Conclusion

If you have RA, you might feel like you’re on a lifelong roller coaster of pain and fatigue. However, by following your doctor’s advice, you can alleviate your symptoms and slow the progression.

Want expert advice on persistent severe pain, swelling, and stiffness due to rheumatoid arthritis?

You can contact us at +91-9582280201 to avail prompt assistance.
 

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